食品合成生物学与生物制造团队

416. Wang, Y., et al.Construction of Synthetic Promoters by Assembling the Sigma Factor Binding-35 and-10 Boxes. BIOTECHNOLOGY JOURNAL, 2019, 14, 1800298

417. Wang, Y., et al.In Silico Protein Design Promotes the Rapid Evolution of Industrial Enzymes. BIOCHEMISTRY, 2019,58:1451-1453

418. Yang, S ., et al.A new sRNA‐mediated posttranscriptional regulation system for Bacillus subtilis. BIOTECHNOLOGY AND BIOENGINEERING, 2018;115:2986–2995

419. Liu, QT., et al.Molecular Engineering of Bacillus paralicheniformis Acid Urease To Degrade Urea and Ethyl Carbamate in Model Chinese Rice Wine. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, 66, 13011−13019

420. Liu, QT., et al.Food-grade expression of an iron-containing acid urease in Bacillus subtilis. JOURNAL OF BIOTECHNOLOGY, 2019,293:66-71

421. Wang, H., et al.Secretory expression of biologically active chondroitinase ABC I for production of chondroitin sulfate oligosaccharides. CARBOHYDRATE POLYMERS, 2019,224,:115135

422. Zhou, ZX., et al.Secretory expression of the rat aryl sulfotransferases IV with improved catalytic efficiency by molecular engineering. 3 BIOTECH, 2019, 9:246

423. Zhou, X., et al.Metabolic Engineering of Saccharomyces cerevisiae to Improve Glucan Biosynthesis. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2019，29(5):758-764

424. Ma, WL., et al.Combinatorial Fine-Tuning of GNA1 and GlmS Expression by 5'-Terminus Fusion Engineering Leads to Overproduction of N-Acetylglucosamine in Bacillus subtilis. BIOTECHNOLOGY JOURNAL, 2018, 1800264

425. Ma, WL., et al.Combinatorial pathway enzyme engineering and host engineering overcomes pyruvate overflow and enhances overproduction of N-acetylglucosamine in Bacillus subtilis. MICROBIAL CELL FACTORIES, 2019, 18:1

426. Cui, SX., et al.Engineering a Bifunctional Phr60-Rap60-Spo0A Quorum-Sensing Molecular Switch for Dynamic Fine-Tuning of Menaquinone-7 Synthesis in Bacillus subtilis. ACS SYNTHETIC BIOLOGY, 2019. 8: 1826-1837

427. Yuan, HB., et al.Enhanced 2,5-Furandicarboxylic Acid (FDCA) Production in Raoultella ornithinolytica BF60 by Manipulation of the Key Genes in FDCA Biosynthesis Pathway. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2019,28 (12): 1999-2008

428. Deng, C., et al.Synthetic repetitive extragenic palindromic (REP) sequence as an efficient mRNA stabilizer for protein production and metabolic engineering in prokaryotic cells. BIOTECHNOLOGY AND BIOENGINEERING, 2019;116:5–18

429. Gu, Y., et al.Synthetic redesign of central carbon and redox metabolism for high yield production of N-acetylglucosamine in Bacillus subtilis. METABOLIC ENGINEERING,  2019 ,51:59–69

430. Deng, JY., et al.Creating an in vivo bifunctional gene expression circuit through an aptamer-based regulatory mechanism for dynamic metabolic engineering in Bacillus subtilis. METABOLIC ENGINEERING, 2019,55:179-190

431. Jieying Deng, Liuyan Gu , Taichi Chen, Hao Huang, Xiaoqiang Yin, Xueqin Lv, Yanfeng Liu, Nan Li,  Zhenmin Liu, Jianghua Li, Guocheng Du,  Long Liu., et al.Engineering the Substrate Transport and Cofactor Regeneration

Systems for Enhancing 2′-Fucosyllactose Synthesis in Bacillus subtilis. ACS Synthetic Biology, 2019. 8: 2418-2427

432. Xiaomin Dong, Nan Li, Zhenmin Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Miao Wang, Long Liu., et al.Modular pathway engineering of key precursor supply pathways for lacto‑N‑neotetraose production in Bacillus subtilis. Biotechnology for Biofuels, 2019，12：212

433. Nshimiyimana, P., et al.Engineering of L-amino acid deaminases for the production of alpha-keto acids from L-amino acids. BIOENGINEERED, 2019,10(1):43-51

434. Jiang, Z., et al.Secretory Expression Fine-Tuning and Directed Evolution of Diacetylchitobiose Deacetylase by Bacillus subtilis. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2019,85(17):e01076-19

435. Pan, MY., et al.Molecular engineering of chitinase from Bacillus sp. DAU101 for enzymatic production of chitooligosaccharides. ENZYME AND MICROBIAL TECHNOLOGY, 2019,124:54–62

436. Huang, TT., et al.Combinatorial Fine-Tuning of Phospholipase D Expression by Bacillus subtilis WB600 for the Production of Phosphatidylserine. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2018, 28(12), 2046–2056

437. Chen Deng, Xueqin Lv, Yanfeng Liu, Jianghua Li, Wei Lu, Guocheng Du, Long Liu., et al.Metabolic engineering of Corynebacterium glutamicum S9114 based on whole-genome sequencing for efficient N-acetylglucosamine synthesis. Synthetic and Systems Biotechnology, 2019,4:120-129

438. Peng, Z., et al.Keratin Waste Recycling Based on Microbial Degradation: Mechanisms and Prospects. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2019,7:9727-9736

439. Peng, Z., et al.Enhanced extracellular expression of Bacillus stearothermophilus alpha-amylase in Bacillus subtilis through signal peptide optimization, chaperone overexpression and alpha-amylase mutant selection. MICROBIAL CELL FACTORIES, 2019,18:84

440. Zhu, ZM., et al.Enhanced acid-stress tolerance in Lactococcus lactis NZ9000 by overexpression of ABC transporters. MICROBIAL CELL FACTORIES, 2019,18:36

441. Qiu, XL., et al.Stress tolerance phenotype of industrial yeast: industrial cases, cellular changes, and improvement strategies. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2019,103: 16: 6449-6462

442. Tang, H., et al.Insight into subtilisin E-S7 cleavage pattern based on crystal structure and hydrolysates peptide analysis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019,512: 623e628

443. Fang, F., et al.Characterization of a Lactobacillus brevis strain with potential oral probiotic properties. BMC MICROBIOLOGY, 2018. 18:221

444. Liu, YF., et al.Synthetic Biology Toolbox and Chassis Development in Bacillus subtilis. TRENDS IN BIOTECHNOLOGY, 2019. 37(5): 548-562

445. Zhang, XL., et al.Microbial production of sialic acid and sialylated human milk oligosaccharides: Advances and perspectives. BIOTECHNOLOGY ADVANCES, 2019, 37: 787-900

446. Tian, RZ., et al.Synthetic N-terminal coding sequences for fine-tuning gene expression and metabolic engineering in Bacillus subtilis. METABOLIC ENGINEERING, 2019,55:131-141

447. Yang Fan, Chen Liangqiang, Liu Yanfeng, Li Jianghua, Wang, Li, Chen Jian., et al.Identification of microorganisms producing lactic acid during solid-state fermentation of Maotai flavour liquor. Journal of the Institute of Brewing, 2019. 125(1): 171-177

448. Zhao, L., et al.Pathway Engineering of Bacillus subtilis for Enhanced N-Acetylneuraminic Acid Production via Whole-Cell Biocatalysis. BIOTECHNOLOGY JOURNAL, 2019, 14, 1800682

449. Weizhu Zeng, Wen Cai, Li Liu, Guocheng Du, Jian Chen, Jingwen Zhou., et al.Efficient biosynthesis of 2-keto-D-gluconic acid by fed-batch culture of metabolically engineered Gluconobacter japonicus. Synthetic and Systems Biotechnology, 2019,4:134-141

450. Weizhu Zeng · Bingbing Xu · Guocheng Du · Jian Chen · Jingwen Zhou., et al.Integrating enzyme evolution and high‑throughput screening

for efficient biosynthesis of l‑DOPA. Journal of Industrial Microbiology & Biotechnology , (2019) 46:1631–1641

451. Wang, Yang., et al. Engineering strong and stress-responsive promoters in Bacillus subtilis by interlocking sigma factor binding motifs.. Synthetic and Systems Biotechnology, 2019,4 (4):197-203"

452. Heng Tang, Ke Shi, Cheng Shi, Hideki Aihara*, Juan Zhang* and Guocheng Du., et al.Enhancing subtilisin thermostability through a modified normalized B-factor analysis and loop-grafting strategy. The Journal of biological chemistry, 2019,294(48): 18398-18407

453. Zhengming Zhu, Peishan Yang, Zhimeng Wu, ·Juan Zhang,Guocheng Du., et al.Systemic understanding of Lactococcus lactis response to acid stress using transcriptomics approaches. Journal of Industrial Microbiology & Biotechnology ,  2019,46 : 11: 1621-1629 "

454. Yunbin Lyu, Weizhu Zengd, Guocheng Du, Jian Chen, Jingwen Zhou., et al.Efficient bioconversion of epimedin C to icariin by a glycosidase from Aspergillus nidulans. Bioresource Technology, 2019,289:121612

455. Lv Yongkun, Xu Sha, Lyu Yunbin, Zhou Shenghu, Du Guocheng, Chen Jian, Zhou Jingwen., et al. Engineering enzymatic cascades for the efficient biotransformation of eugenol and taxifolin to silybin and isosilybin. Green Chemistry,  2019. 21:1660."

456. Luo Zhengshan, Zeng Weizhu, Du Guocheng, Chen Jian, Zhou Jingwen., et al.Enhanced Pyruvate Production in Candida glabrata by Engineering ATP Futile Cycle System. ACS Synthetic Biology, 2019. 8: 787−795

457. Zhou Shenghu,  Lyu Yunbin, Li Huazhong, Koffas, Mattheos A. G., Zhou Jingwen., et al.Fine-tuning the (2S)-naringenin synthetic pathway using an iterative high-throughput balancing strategy. BIOTECHNOLOGY AND BIOENGINEERING, 2019. 116: 1392-1404

458. Panpan Wang, Weizhu Zeng, Guocheng Du, Jingwen Zhou, Jian Chen., et al.Systematic characterization of sorbose/sorbosone dehydrogenases and sorbosone dehydrogenases from Ketogulonicigenium vulgare WSH-001. JOURNAL OF BIOTECHNOLOGY, 2019,310:24-34

459. Yunbin Lyu, Weizhu Zengd, Guocheng Du, Jian Chen, Jingwen Zhou., et al.Efficient separation of α-ketoglutarate from Yarrowia lipolytica WSH-Z06 culture broth by converting pyruvate to L-tyrosine. Bioresource Technology, 2019,292:121897

460. Li Liu, Weizhu Zeng, Guocheng Du, Jian Chen, Jingwen Zhou., et al.Identification of NAD-Dependent Xylitol Dehydrogenase from Gluconobacter oxydans WSH-003. ACS Omega, 2019, 4, 15074−15080

461. Sha Xu, Yu Zhang, Youran Li, Xiaole Xia, Jingwen Zhou, Guiyang Shi., et al.Production of L-tyrosine using tyrosine phenol-lyase by whole cell biotransformation approach. Enzyme and Microbial Technology, 2019，131：109430

462. Runqing Tan, Yunbin Lyu, Weizhu Zeng, Jingwen Zhou., et al.Enhancing scleroglucan production by Sclerotium rolfsii WSH-G01 through a pH-shift strategy based on kinetic analysis. Bioresource Technology, 2019,293:121897

463. Eric Fordjour, Frederick Komla Adipah,  Zhou Shenghu, Du Guocheng, Zhou, Jingwen., et al.Metabolic engineering of Escherichia coli BL21 (DE3) for de novo production of l‑DOPA from d‑glucose. MICROBIAL CELL FACTORIES, 2019,18:74

464. Zhao Weixin, Liu Song*, Du Guocheng, Zhou Jingwen., et al.An efficient expression tag library based on self‑assembling amphipathic peptides. MICROBIAL CELL FACTORIES, 2019, 18:91

465. Zhao Weixin， Du Guocheng ,Liu  Song., et al.An efficient thermostabilization strategy based on self-assembling amphipathic peptides for fusion tags. Enzyme and Microbial Technology, 2019,121:68-77

466. Feng Yue, Liu Song, Jiao Yun,Wang Yunlong ,Wang  Miao,  Du Guocheng., et al.Gene cloning and expression of the L-asparaginase from Bacillus cereus BDRD-ST26 in Bacillus subtilis WB600. JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2019,127(4): 418-424